Definition:Dependence Receptors, DR, are transmembrane proteins
capable of inducing cell death in the absence of their ligand
Mechanism: So far, this includes caspase cleavage of DR and a common transmembrane region dubbed DART motif .
Significance: DR control cell fate; DR are used in early development (e.g., axon guidance) and late development (e.g., cancer). Identifying these proteins, may assist researchers in better understanding cell fate .